East Netherlands


Under the name TOPFIT Impact Programme, the University of Twente, Wageningen University & Research, Radboud University and RadboudUMC join together in an impact programme aimed at preventing and reducing disease and the burden of disease.



Much progress has been made in recent years in understanding disease processes and the development of new treatment methods. At the same time, the realization that many diseases will remain incurable for the foreseeable future grows. Through smart integration of innovative technologies and knowledge about nutrition and health we can be one step ahead of disease and its burdens. ​

These integral solutions mean that there will be an ever more personal approach in healthcare. The payoff is a maximum increase in the quality of life of patients and the best perspective on affordable healthcare in an aging society. The goal of the TopFit programme is to contribute to controlling and limiting the cost of healthcare in the future, without making concessions to the quality of life of patients.

TOPfit from University of Twente on Vimeo.


TOPFIT aspires to be a leading health impact programme on three levels: society & health, innovation & (regional) economy and science & technology. Therefore, the researchers work together with key partners in the east of the Netherlands.

TOPFIT deploys a programmatic approach, aiming at moonshots at a timescale of >10 years, organised in dynamic (disease oriented) mission driven programmes that deliver impact for social innovation, health system innovation, economic growth and further scientific excellence, at a time scale of >5 years. Immediate results within 2 years are new coalitions of health, food and tech expertises that serve social impact and citizen science, new business development and scale ups, and challenging new combinations in scientific excellence.

Diabetes on Return

In Europe around 60 million people suffer from Diabetes Mellitus (DM) and in the Netherlands this number is around 1.2 million. About 90% of these suffer from Type 2 Diabetes  Read more »

Cardiovascular Diseases

The development of cardiovascular disease takes several decades, whilst it only takes milliseconds for a serious problem to occur, such as myocardial infarction, cardiac arrest Read more »

Movement Disorders

The mission programme Movement disorders supports the Interdisciplinary Consortium for clinical Movement Sciences & technology (ICMS). ICMS is aimed at improving the quality of life Read more »

In these mission-driven programmes, TOPFIT closely cooperates with Health Valley and the Health Innovation Park (HIP) on valorisation, business cooperation, dissemination and branding, with the OnePlanet Centre on key technologies in health and food, and with the  interdisciplinary consortium for clinical movement sciences & technology (ICMS).

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